2021
DECEMBER
Research on Hotair and 7SL-RNA Gene Expression Levels in Psoriasis Vulgaris. Yazıcı S, Guner RY, Akyol M, Tuzemen Bayyurt EB, Arslan S. Indian J Dermatol. 2021 Nov-Dec;66(6):704.
Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms. Heymans S, Cooper LT. Nat Rev Cardiol. 2021 Dec 9.
Marathon-Induced Cardiac Strain as Model for the Evaluation of Diagnostic microRNAs for Acute Myocardial Infarction. Shirvani Samani O, Scherr J, Kayvanpour E, Haas J, Lehmann DH, Gi WT, Frese KS, Nietsch R, Fehlmann T, Sandke S, Weis T, Keller A, Katus HA, Halle M, Frey N, Meder B, Sedaghat-Hamedani F. J Clin Med. 2021 Dec 21;11(1):5.
Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder. Lin R, Lopez JP, Cruceanu C, Pierotti C, Fiori LM, Squassina A, Chillotti C, Dieterich C, Mellios N, Turecki G. Transl Psychiatry. 2021 Dec 10;11(1):629.
Decreased miR-497-5p Suppresses IL-6 Induced Atrophy in Muscle Cells. Freire PP, Cury SS, Lopes LO, Fernandez GJ, Liu J, de Moraes LN, de Oliveira G, Oliveira JS, de Moraes D, Cabral-Marques O, Dal-Pai-Silva M, Hu X, Wang DZ, Carvalho RF. Cells. 2021 Dec 14;10(12):3527.
Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. Gong X, Tian M, Cao N, Yang P, Xu Z, Zheng S, Liao Q, Chen C, Zeng C, Jose PA, Wang DZ, Jian Z, Xiao Y, Jiang DS, Wei X, Zhang B, Wang Y, Chen K, Wu G, Zeng C. J Clin Invest. 2021 Dec 15;131(24):e147031.
NOVEMBER
Time-controlled and muscle-specific CRISPR/Cas9-mediated deletion of CTG-repeat expansion in the DMPK gene. Cardinali B, Provenzano C, Izzo M, Voellenkle C, Battistini J, Strimpakos G, Golini E, Mandillo S, Scavizzi F, Raspa M, Perfetti A, Baci D, Lazarevic D, Garcia-Manteiga JM, Gourdon G, Martelli F, Falcone G. Mol Ther Nucleic Acids. 2021 Nov 29;27:184-199.
Association of cardiometabolic microRNAs with COVID-19 severity and mortality. Gutmann C, Khamina K, Theofilatos K, Diendorfer AB, Burnap SA, Nabeebaccus A, Fish M, McPhail MJW, O'Gallagher K, Schmidt LE, Cassel C, Auzinger G, Napoli S, Mujib SF, Trovato F, Sanderson B, Merrick B, Roy R, Edgeworth JD, Shah AM, Hayday AC, Traby L, Hackl M, Eichinger S, Shankar-Hari M, Mayr M. Cardiovasc Res. 2021 Nov 10:cvab338.
The long non-coding RNA NRON promotes the development of cardiac hypertrophy in the murine heart. Hoepfner J, Leonardy J, Lu D, Schmidt K, Hunkler HJ, Biß S, Foinquinos A, Xiao K, Regalla K, Ramanujam D, Engelhardt S, Bär C, Thum T. Mol Ther. 2021 Nov 29:S1525-0016(21)00635-3.
Noncoding RNAs: biology and applications-a Keystone Symposia report. Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X. Ann N Y Acad Sci. 2021 Nov 17.
Deficiency of lncRNA SNHG12 impairs ischemic limb neovascularization by altering an endothelial cell cycle pathway. Gross DA, Cheng HS, Zhuang R, McCoy MG, Pérez-Cremades D, Salyers Z, Wara AKMK, Haemmig S, Ryan TE, Feinberg MW. JCI Insight. 2021 Nov 18:e150761.
Locus-Conserved Circular RNA cZNF292 Controls Endothelial Cell Flow Responses. Heumüller AW, Jones AN, Mourão A, Klangwart M, Shi C, Wittig I, Fischer A, Muhly Reinholz M, Buchmann GK, Dieterich C, Potente M, Braun T, Grote P, Jaé N, Sattler M, Dimmeler S. Circ Res. 2021 Nov 18.
Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease. Neiburga KD, Vilne B, Bauer S, Bongiovanni D, Ziegler T, Lachmann M, Wengert S, Hawe JS, Güldener U, Westerlund AM, Li L, Pang S, Yang C, Saar K, Huebner N, Maegdefessel L, DigiMed Bayern Consortium, Lange R, Krane M, Schunkert H, von Scheidt M. Biomolecules. 2021 Nov 12;11(11):1683.
Improved nanopore direct RNA sequencing of cardiac myocyte samples by selective mt-RNA depletion. Naarmann-de Vries IS, Eschenbach J, Dieterich C. J Mol Cell Cardiol. 2021 Nov 3:S0022-2828(21)00209-1.
Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes. Zhou Z, Collado A, Sun C, Tratsiakovich Y, Mahdi A, Winter H, Chernogubova E, Seime T, Narayanan S, Jiao T, Jin H, Alvarsson M, Zheng X, Yang J, Hedin U, Catrina SB, Maegdefessel L, Pernow J. Diabetes. 2021 Nov 9:db210093.
LIPCAR Is Increased in Chronic Symptomatic HF Patients. A Sub-Study of the GISSI-HF Trial. Meessen JMTA, Bär C, di Dona FM, Staszewsky LI, Di Giulio P, Di Tano G, Costa A, Leonardy J, Novelli D, Nicolis EB, Masson S, Pinet F, Thum T, Latini R. Clin Chem. 2021 Nov 9:hvab197.
OCTOBRE
RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin. Bandiera R, Wagner RE, Britto-Borges T, Dieterich C, Dietmann S, Bornelöv S, Frye M. Nat Commun. 2021 Oct 7;12(1):5864.
C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation. Ingen E, Homberg DAL, Bent ML, Mei H, Papac-Milicevic N, Kremer V, Boon RA, Quax PHA, Wojta J, Nossent AY. Hum Mol Genet. 2021 Oct 21:ddab304.
MiR-409-3p targets a MAP4K3-ZEB1-PLGF signaling axis and controls brown adipose tissue angiogenesis and insulin resistance. Becker-Greene D, Li H, Perez-Cremades D, Wu W, Bestepe F, Ozdemir D, Niosi CE, Aydogan C, Orgill DP, Feinberg MW, Icli B. Cell Mol Life Sci. 2021 Oct 26.
Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy. Sacchetto C, Mohseni Z, Colpaert RMW, Vitiello L, De Bortoli M, Vonhögen IGC, Xiao K, Poloni G, Lorenzon A, Romualdi C, Bariani R, Mazzotti E, Daliento L, Bauce B, Corrado D, Thum T, Rampazzo A, de Windt LJ, Calore M. Cells. 2021 Sep 28;10(10):2578.
The very low risk of myocarditis and pericarditis after mRNA COVID-19 vaccination should not discourage vaccination. Haaf P, Kuster GM, Mueller C, Berger CT, Monney P, Burger P, Stämpfli SF, Attenhofer Jost CH, Zellweger MJ, Osswald S, Donner BC, Koestner SC, Tanner FC. Swiss Med Wkly. 2021 Oct 19;151:w30087.
Long Non-coding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization. Fasolo F, Jin H, Winski G, Chernogubova E, Pauli J, Winter H, Li DY, Glukha N, Bauer S, Metschl S, Wu Z, Koschinsky ML, Reilly M, Pelisek J, Kempf W, Eckstein HH, Soehnlein O, Matic L, Hedin U, Bäcklund A, Bergmark C, Paloschi V, Maegdefessel L. Circulation. 2021 Oct 14.
Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside: A Position Paper from the EU-CardioRNA COST Action CA17129. Vanhaverbeke M, Attard R, Bartekova M, Ben-Aicha S, Brandenburger T, de Gonzalo-Calvo D, Emanueli C, Farrugia R, Grillari J, Hackl M, Kalocayova B, Martelli F, Scholz M, Wettinger SB, Devaux Y; EU-CardioRNA COST Action CA17129. Cardiovasc Res. 2021 Oct 14:cvab327.
SEPTEMBRE
Molecular Network Approach Reveals Rictor as a Central Target of Cardiac ProtectomiRs. Makkos A, Ágg B, Varga ZV, Giricz Z, Gyöngyösi M, Lukovic D, Schulz R, Barteková M, Görbe A, Ferdinandy P. Int J Mol Sci. 2021 Sep 2;22(17):9539.
Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy. Sacchetto C, Mohseni Z, Colpaert RMW, Vitiello L, De Bortoli M, Vonhögen IGC, Xiao K, Poloni G, Lorenzon A, Romualdi C, Bariani R, Mazzotti E, Daliento L, Bauce B, Corrado D, Thum T, Rampazzo A, de Windt LJ, Calore M. Cells. 2021 Sep 28;10(10):2578.
Role of miR-2392 in driving SARS-CoV-2 infection. McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, Sajadi MM, Harris AD, Clement J, Dybas JM, Aykin-Burns N, Guarnieri JW, Singh LN, Grabham P, Baylin SB, Yousey A, Pearson AN, Corry PM, Saravia-Butler A, Aunins TR, Sharma S, Nagpal P, Meydan C, Foox J, Mozsary C, Cerqueira B, Zaksas V, Singh U, Wurtele ES, Costes SV, Davanzo GG, Galeano D, Paccanaro A, Meinig SL, Hagan RS, Bowman NM; UNC COVID-19 Pathobiology Consortium, Wolfgang MC, Altinok S, Sapoval N, Treangen TJ, Moraes-Vieira PM, Vanderburg C, Wallace DC, Schisler JC, Mason CE, Chatterjee A, Meller R, Beheshti A. Cell Rep. 2021 Sep 30:109839.
Prognostic value of circulating microRNAs compared to high-sensitivity troponin T in patients presenting with suspected acute coronary syndrome to the emergency department. Biener M, Giannitsis E, Thum T, Bär C, Stoyanov KM, Salbach C, de Gonzalo-Calvo D, Frey N, Mueller-Hennessen M. Clin Biochem. 2021 Sep 24:S0009-9120(21)00250-2.
Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell-Specific Changes in the Kidney and Increases Blood Pressure. Paterson MR, Jackson KL, Dona MSI, Farrugia GE, Visniauskas B, Watson AMD, Johnson C, Prieto MC, Evans RG, Charchar FJ, Pinto AR, Marques FZ, Head GA. Hypertension. 2021 Sep 20:HYPERTENSIONAHA12117384.
P-selectin targeted RAGE-shRNA lipoplexes alleviate atherosclerosis-associated inflammation. Mocanu CA, Fuior EV, Voicu G, Rebleanu D, Safciuc F, Deleanu M, Fenyo IM, Escriou V, Manduteanu I, Simionescu M, Calin M. J Control Release. 2021 Sep 14;338:754-772.
Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension. Rodor J, Chen SH, Scanlon JP, Monteiro JP, Caudrillier A, Sweta S, Stewart KR, Shmakova A, Dobie R, Henderson BEP, Stewart K, Hadoke PWF, Southwood M, Moore SD, Upton PD, Morrell NW, Li Z, Chan SY, Handen A, Lafyatis R, de Rooij LPMH, Henderson NC, Carmeliet P, Spiroski AM, Brittan M, Baker AH. Cardiovasc Res. 2021 Sep 16:cvab296.
Corrigendum to "Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and disease" [Genomics 113 (2021) 1349-1365]. Vrbský J, Vinarský V, Perestrelo AR, Oliver-De La Cruz J, Martino F, Pompeiano A, Izzi V, Hlinomaz O, Rotrekl V, Sudol M, Pagliari S, Forte G. Genomics. 2021 Sep 2:S0888-7543(21)00341-4.
The RNA binding protein HuR is a gatekeeper of liver homeostasis. Subramanian P, Gargani S, Palladini A, Chatzimike M, Grzybek M, Peitzsch M, Papanastasiou AD, Pyrina I, Ntafis V, Gercken B, Lesche M, Petzold A, Sinha A, Nati M, Thangapandi VR, Kourtzelis I, Andreadou M, Witt A, Dahl A, Burkhardt R, Haase R, Domingues AMJ, Henry I, Zamboni N, Mirtschink P, Chung KJ, Hampe J, Coskun Ü, Kontoyiannis DL, Chavakis T. Hepatology. 2021 Sep 14.
miR-210 hypoxamiR in angiogenesis and diabetes. Zaccagnini G, Greco S, Voellenkle C, Gaetano C, Martelli F. Antioxid Redox Signal. 2021 Sep 14.
Circulating circRNA as biomarkers for dilated cardiomyopathy etiology. Costa MC, Calderon-Dominguez M, Mangas A, Campuzano O, Sarquella-Brugada G, Ramos M, Quezada-Feijoo M, Pinilla JMG, Robles-Mezcua A, Del Aguila Pacheco-Cruz G, Belmonte T, Enguita FJ, Toro R. J Mol Med (Berl). 2021 Sep 8.
Citrate-saline formulated mRNA delivery into the heart muscle with an electromechanical mapping and injection catheter does not lead to therapeutic effects in a porcine chronic myocardial ischemia model. Järveläinen NP, Halonen PJ, Nurro J, Hätinen OP, Korpela H, Mäkinen P, Gan LM, Fritsche-Danielson R, Ylä-Herttuala S. Hum Gene Ther. 2021 Sep 8.
AUGUST
A microRNA program regulates the balance between cardiomyocyte hyperplasia and hypertrophy and stimulates cardiac regeneration. Raso A, Dirkx E, Sampaio-Pinto V, El Azzouzi H, Cubero RJ, Sorensen DW, Ottaviani L, Olieslagers S, Huibers MM, de Weger R, Siddiqi S, Moimas S, Torrini C, Zentillin L, Braga L, Nascimento DS, da Costa Martins PA, van Berlo JH, Zacchigna S, Giacca M, De Windt LJ. Nat Commun. 2021 Aug 10;12(1):4808.
Reduced Levels of miR-342-5p in Plasma Are Associated With Worse Cognitive Evolution in Patients With Mild Alzheimer's Disease. Dakterzada F, David Benítez I, Targa A, Lladó A, Torres G, Romero L, de Gonzalo-Calvo D, Moncusí-Moix A, Tort-Merino A, Huerto R, Sánchez-de-la-Torre M, Barbé F, Piñol-Ripoll G. Front Aging Neurosci. 2021 Aug 23;13:705989.
The conserved long noncoding RNA CARMA regulates cardiomyocyte differentiation. Kay M, Soltani BM, Nemir M, Aghagolzadeh P, Pezzuto I, Chouvardas P, Ruberto F, Movahedi F, Ansari H, Baharvand H, Pedrazzini T. Cardiovasc Res. 2021 Aug 30:cvab281.
MiR-223-3p levels in the plasma and atherosclerotic plaques are increased in aged patients with carotid artery stenosis; association with HDL-related proteins. Barbalata T, Moraru OE, Stancu CS, Sima AV, Niculescu LS. Mol Biol Rep. 2021 Aug 19.
LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway. Liu N, Kataoka M, Wang Y, Pu L, Dong X, Fu X, Zhang F, Gao F, Liang T, Pei J, Xiao C, Qiu Q, Hong T, Chen Q, Zhao J, Zhu L, He J, Hu X, Nie Y, Zhu W, Yu H, Cowan DB, Hu X, Wang J, Wang DZ, Chen J. Basic Res Cardiol. 2021 Aug 11;116(1):48.
JULY
High Throughput miRNA Screening Identifies miR-574-3p Hyperproductive Effect in CHO Cells. Švab Ž, Braga L, Guarnaccia C, Labik I, Herzog J, Baralle M, Giacca M, Skoko N. Biomolecules. 2021 Jul 30;11(8):1125.
A comparison of metabolic labeling and statistical methods to infer genome-wide dynamics of RNA turnover. Boileau E, Altmüller J, Naarmann-de Vries IS, Dieterich C. Brief Bioinform. 2021 Jul 7:bbab219.
Circulating long non-coding RNA signature in knee osteoarthritis patients with postoperative pain one-year after total knee replacement. Giordano R, Petersen KK, Santoro M, Pazzaglia C, Simonsen O, Valeriani M, Arendt-Nielsen L. Scand J Pain. 2021 Jul 29.
A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy. Martens L, Rühle F, Witten A, Meder B, Katus HA, Arbustini E, Hasenfuß G, Sinner MF, Kääb S, Pankuweit S, Angermann C, Bornberg-Bauer E, Stoll M. RNA Biol. 2021 Jul 27:1-7.
Non-coding RNAs in cardiac regeneration: Mechanism of action and therapeutic potential. Wang Y, Chen J, Cowan DB, Wang DZ. Semin Cell Dev Biol. 2021 Jul 17:S1084-9521(21)00194-4.
LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition. Pham TP, van Bergen AS, Kremer V, Glaser SF, Dimmeler S, Boon RA. Int J Mol Sci. 2021 Jul 28;22(15):8088.
Smooth Muscle Cell-Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting With Serum Response Factor. Ni H, Haemmig S, Deng Y, Chen J, Simion V, Yang D, Sukhova G, Shvartz E, Wara AKMK, Cheng HS, Pérez-Cremades D, Assa C, Sausen G, Rulin Z, Dai Q, Feinberg MW. Arterioscler Thromb Vasc Biol. 2021 Jul 22:ATVBAHA120315911.
Decoding the Complexity of Circular RNAs in Cardiovascular Disease. Rai AK, Lee B, Hebbard C, Uchida S, Garikipati VNS. Pharmacol Res. 2021 Jul 13:105766.
Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. Zhu C, Wu J, Sun H, Briganti F, Meder B, Wei W, Steinmetz LM. Nat Commun. 2021 Jul 9;12(1):4203.
ERBB4 and Multiple MicroRNAs That Target ERBB4 Participate in Pregnancy-Related Cardiomyopathy. Feyen E, Ricke-Hoch M, Van Fraeyenhove J, Vermeulen Z, Scherr M, Dugaucquier L, Viereck J, Bruyns T, Thum T, Segers VFM, Hilfiker-Kleiner D, De Keulenaer GW. Circ Heart Fail. 2021 Jul 12:CIRCHEARTFAILURE120006898.
Vascular Endothelial Senescence: Pathobiological Insights, Emerging Long Noncoding RNA Targets, Challenges and Therapeutic Opportunities. Sun X, Feinberg MW. Front Physiol. 2021 Jun 16;12:693067.
JUNE
Leveraging non-coding RNAs to fight cardiovascular disease: the EU-CardioRNA network. Robinson EL, Emanueli C, Martelli F, Devaux Y. Eur Heart J. 2021 Jun 10:ehab326.
CAD increases the long noncoding RNA PUNISHER in small extracellular vesicles and regulates endothelial cell function via vesicular shuttling. Hosen MR, Li Q, Liu Y, Zietzer A, Maus K, Goody P, Uchida S, Latz E, Werner N, Nickenig G, Jansen F. Mol Ther Nucleic Acids. 2021 Jun 4;25:388-405.
Lessons from the spatiotemporal expression patterns of RNA vs. proteins during the cell cycle. Chiva-Blanch G, Mayr M. Cardiovasc Res. 2021 Jun 28:cvab196.
Association between miR-146a and Tumor Necrosis Factor Alpha (TNF-α) in Stable Coronary Artery Disease. Pereira-da-Silva T, Napoleão P, Costa MC, Gabriel AF, Selas M, Silva F, Enguita FJ, Cruz Ferreira R, Mota Carmo M. Medicina (Kaunas). 2021 Jun 4;57(6):575.
Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning. Körtel N, Rücklé C, Zhou Y, Busch A, Hoch-Kraft P, Sutandy FXR, Haase J, Pradhan M, Musheev M, Ostareck D, Ostareck-Lederer A, Dieterich C, Hüttelmaier S, Niehrs C, Rausch O, Dominissini D, König J, Zarnack K. Nucleic Acids Res. 2021 Jun 22:gkab485.
SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity. Boehm V, Kueckelmann S, Gerbracht JV, Kallabis S, Britto-Borges T, Altmüller J, Krüger M, Dieterich C, Gehring NH. Nat Commun. 2021 Jun 25;12(1):3965.
Novel RNAi-Based Therapies for Atherosclerosis. Ruotsalainen AK, Mäkinen P, Ylä-Herttuala S. Curr Atheroscler Rep. 2021 Jun 19;23(8):45.
Non-coding RNAs in cardiac inflammation: key drivers in the pathophysiology of heart failure. Sansonetti M, De Windt LJ. Cardiovasc Res. 2021 Jun 7:cvab192.
AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction. Hinkel R, Batkai S, Bähr A, Bozoglu T, Straub S, Borchert T, Viereck J, Howe A, Hornaschewitz N, Oberberger L, Jurisch V, Kozlik-Feldmann R, Freudenthal F, Ziegler T, Weber C, Sperandio M, Engelhardt S, Laugwitz KL, Moretti A, Klymiuk N, Thum T, Kupatt C. J Am Coll Cardiol. 2021 Jun 15;77(23):2923-2935.
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care. Gutmann C, Takov K, Burnap SA, Singh B, Ali H, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail MJ, O'Gallagher K, Schmidt LE, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib SF, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Fernández-Leiro R, Braun S, Kronstein-Wiedemann R, Doores KJ, Edgeworth JD, Shah AM, Bornstein SR, Tonn T, Hayday AC, Giacca M, Shankar-Hari M, Mayr M. Nat Commun. 2021 Jun 7;12(1):3406.
RNA interference therapeutics for cardiac regeneration. Huntington J, Pachauri M, Ali H, Giacca M. Nat Commun. 2021 Jun 7;12(1):3406.
MAY
Correction: Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia. Zaccagnini G, Greco S, Longo M, Maimone B, Voellenkle C, Fuschi P, Carrara M, Creo P, Maselli D, Tirone M, Mazzone M, Gaetano C, Spinetti G, Martelli F. Cell Death Dis. 2021 May 18;12(6):507.
N6-Methyladenine in Eukaryotic DNA: Tissue Distribution, Early Embryo Development, and Neuronal Toxicity. Fernandes SB, Grova N, Roth S, Duca RC, Godderis L, Guebels P, Mériaux SB, Lumley AI, Bouillaud-Kremarik P, Ernens I, Devaux Y, Schroeder H, Turner JD. Front Genet. 2021 May 24;12:657171.
Non-Random Genome Editing and Natural Cellular Engineering in Cognition-Based Evolution. Miller WB Jr, Enguita FJ, Leitão AL. Cells. 2021 May 7;10(5):1125.
Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications. Garikipati VNS, Uchida S. Noncoding RNA. 2021 May 11;7(2):31.
Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients. de Gonzalo-Calvo D, Benítez ID, Pinilla L, Carratalá A, Moncusí-Moix A, Gort-Paniello C, Molinero M, González J, Torres G, Bernal M, Pico S, Almansa R, Jorge N, Ortega A, Bustamante-Munguira E, Gómez JM, González-Rivera M, Micheloud D, Ryan P, Martinez A, Tamayo L, Aldecoa C, Ferrer R, Ceccato A, Fernández-Barat L, Motos A, Riera J, Menéndez R, Garcia-Gasulla D, Peñuelas O, Torres A, Bermejo-Martin JF, Barbé F; CIBERESUCICOVID Project (COV20/00110, ISCIII). Transl Res. 2021 May 25:S1931-5244(21)00122-5.
Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis. Gatsiou A, Georgiopoulos G, Vlachogiannis NI, Pfisterer L, Fischer A, Sachse M, Laina A, Bonini F, Delialis D, Tual-Chalot S, Zormpas E, Achangwa R, Jiang L, Kontogiannis C, Patras R, Hermeking H, Zeiher AM, Stamatelopoulos K, Dimmeler S, Stellos K. Atherosclerosis. 2021 May 15;327:49-58.
Relevance of N6-methyladenosine regulators for transcriptome: Implications for development and the cardiovascular system. Sweaad WK, Stefanizzi FM, Chamorro-Jorganes A, Devaux Y, Emanueli C; EU-CardioRNA COST Action CA17129. J Mol Cell Cardiol. 2021 May 12:S0022-2828(21)00100-0.
Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types. Moreau PR, Tomas Bosch V, Bouvy-Liivrand M, Õunap K, Örd T, Pulkkinen HH, Pölönen P, Heinäniemi M, Ylä-Herttuala S, Laakkonen JP, Linna-Kuosmanen S, Kaikkonen MU. Arterioscler Thromb Vasc Biol. 2021 May 13:ATVBAHA121315579.
Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: involvement of redox signalling. Makkos A, Ágg B, Petrovich B, Varga ZV, Görbe A, Ferdinandy P. Free Radic Biol Med. 2021 May 6:S0891-5849(21)00280-X.
Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation. Virga F, Cappellesso F, Stijlemans B, Henze AT, Trotta R, Van Audenaerde J, Mirchandani AS, Sanchez-Garcia MA, Vandewalle J, Orso F, Riera-Domingo C, Griffa A, Ivan C, Smits E, Laoui D, Martelli F, Langouche L, Van den Berghe G, Feron O, Ghesquière B, Prenen H, Libert C, Walmsley SR, Corbet C, Van Ginderachter JA, Ivan M, Taverna D, Mazzone M. Sci Adv. 2021 May 7;7(19):eabf0466.
Intravitreal injection of anti-miRs against miR-142-3p reduces angiogenesis and microglia activation in a mouse model of laser-induced choroidal neovascularization. Roblain Q, Louis T, Yip C, Baudin L, Struman I, Caolo V, Lambert V, Lecomte J, Noël A, Heymans S. Aging (Albany NY). 2021 May 5;13.
APRIL
Cardiovascular rna markers and artificial intelligence may improve covid-19 outcome: position paper from the eu-cardiorna cost action ca17129. Badimon L, Robinson EL, Jusic A, Carpusca I, de Windt LJ, Emanueli C, Ferdinandy P, Gu W, Gyöngyösi M, Hackl M, Karaduzovic-Hadziabdic K, Lustrek M, Martelli F, Nham E, Potočnjak I, Satagopam V, Schneider R, Thum T, Devaux Y; EU-CardioRNA COST Action CA17129. Cardiovasc Res. 2021 Apr 11:cvab094.
The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection. McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, McGrath M, Sajadi MM, Harris AD, Clement J, Dybas JM, Aykin-Burns N, Guarnieri JW, Singh LN, Grabham P, Baylin SB, Yousey A, Pearson AN, Corry PM, Saravia-Butler A, Aunins TR, Nagpal P, Meydan C, Foox J, Mozsary C, Cerqueira B, Zaksas V, Singh U, Wurtele ES, Costes SV, Galeano D, Paccanaro A, Meinig SL, Hagan RS, Bowman NM; UNC COVID-19 Pathobiology Consortium, Wolfgang MC, Altinok S, Sapoval N, Treangen TJ, Frieman M, Vanderburg C, Wallace DC, Schisler J, Mason CE, Chatterjee A, Meller R, Beheshti A. bioRxiv. 2021 Apr 27:2021.04.23.441024.
METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells. Chamorro-Jorganes A, Sweaad WK, Katare R, Besnier M, Anwar M, Beazley-Long N, Sala-Newby G, Ruiz-Polo I, Chandrasekera D, Ritchie AA, Benest AV, Emanueli C. Arterioscler Thromb Vasc Biol. 2021 Apr 29:ATVBAHA121316180.
Single cell transcriptome sequencing on the Nanopore platform with ScNapBar. Wang Q, Boenigk S, Boehm V, Gehring NH, Altmueller J, Dieterich C. RNA. 2021 Apr 27:rna.078154.120.
Genomic landscapes of non-coding RNAs regulating VEGFA and VEGFC expression in endothelial cells. Mushimiyimana I, Tomas Bosch V, Niskanen H, Downes N, Moreau P, Hartigan K, Ylä-Herttuala S, Laham-Karam N, Kaikkonen MU. Mol Cell Biol. 2021 Apr 19:MCB.00594-20.
Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker. Lozano-Prieto M, Adlam D, García-Guimaraes M, Sanz-García A, Vera-Tomé P, Rivero F, Cuesta J, Bastante T, Baranowska-Clarke AA, Vara A, Martin-Gayo E, Vicente-Manzanares M, Martín P, Samani NJ, Sánchez-Madrid F, Alfonso F, de la Fuente H. EBioMedicine. 2021 Apr 14;66:103338.
Temporal Relation Between Second Dose BNT162b2 mRNA Covid-19 Vaccine and Cardiac involvement in a Patient with Previous SARS-COV-2 Infection. Ammirati E, Cavalotti C, Milazzo A, Pedrotti P, Soriano F, Schroeder JW, Morici N, Giannattasio C, Frigerio M, Metra M, Camici PG, Oliva F. EU-CardioRNA COST Action CA17129. Int J Cardiol Heart Vasc. 2021 Mar 31;34:100774.
MARCH
Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging. Buckler AJ, Karlöf E, Lengquist M, Gasser TC, Maegdefessel L, Perisic Matic L, Hedin U. Arterioscler Thromb Vasc Biol. 2021 Mar 11:ATVBAHA121315969.
CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease. Talyan S, Filipów S, Ignarski M, Smieszek M, Chen H, Kühne L, Butt L, Göbel H, Hoyer-Allo KJR, Koehler FC, Altmüller J, Brinkkötter P, Schermer B, Benzing T, Kann M, Müller RU, Dieterich C. Cells. 2021 Mar 20;10(3):692.
Biomarker potentials of miRNA-associated circRNAs in breast cancer (MCF-7) cells: an in vitro and in silico study. Misir S, Hepokur C, Aliyazicioglu Y, Enguita FJ. Mol Biol Rep. 2021 Mar 28.
Unsupervised Bayesian Prediction of RNA Translation from Ribosome Profiling Data. Boileau E, Dieterich C. Methods Mol Biol. 2021;2252:295-312.
Dissecting the transcriptome in cardiovascular disease. Robinson EL, Baker AH, Brittan M, McCracken I, Condorelli G, Emanueli C, Srivastava KP, Gaetano C, Thum T, Vanhaverbeke M, Angione C, Heymans S, Devaux Y, Pedrazzini T, Martelli F; EU-CardioRNA COST Action CA17129. Cardiovasc Res. 2021 Mar 23:cvab117.
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease. Monteiro JP, Rodor J, Caudrillier A, Scanlon JP, Spiroski AM, Dudnakova T, Pflüger-Müller B, Shmakova A, von Kriegsheim A, Deng L, Taylor RS, Wilson-Kanamori JR, Chen SH, Stewart K, Thomson A, Mitić T, McClure JD, Iyinikkel J, Hadoke PW, Denby L, Bradshaw AC, Caruso P, Morrell NW, Kovacic JC, Ulitsky I, Henderson NC, Caporali A, Leisegang MS, Brandes RP, Baker AH. Circ Res. 2021 Mar 11.
Evidence for discrete modes of YAP1 signaling via mRNA splice isoforms in development and diseases. Vrbský J, Vinarský V, Perestrelo AR, De La Cruz JO, Martino F, Pompeiano A, Izzi V, Hlinomaz O, Rotrekl V, Sudol M, Pagliari S, Forte G. Genomics. 2021 Mar 10:S0888-7543(21)00101-4.
FEBRUARY
Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis. Price NL, Zhang X, Fernández-Tussy P, Singh AK, Burnap SA, Rotllan N, Goedeke L, Sun J, Canfrán-Duque A, Aryal B, Mayr M, Suárez Y, Fernández-Hernando C. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2006478118.
MicroRNA miR-29b regulates diabetic aortic remodeling and stiffening. Schellinger IN, Wagenhäuser M, Chodisetti G, Mattern K, Dannert A, Petzold A, Jakubizka-Smorag J, Emrich F, Haunschild J, Schuster A, Schwob E, Schulz K, Maegdefessel L, Spin JM, Stumvoll M, Hasenfuß G, Tsao PS, Raaz U. Mol Ther Nucleic Acids. 2021 Feb 24;24:188-199.
Circulating miRNAs Are Associated with the Systemic Extent of Atherosclerosis: Novel Observations for miR-27b and miR-146. Pereira-da-Silva T, Napoleão P, Costa MC, Gabriel AF, Selas M, Silva F, Enguita FJ, Ferreira RC, Carmo MM. Diagnostics (Basel). 2021 Feb 16;11(2):318.
Cigarette Smoking, miR-27b Downregulation, and Peripheral Artery Disease: Insights into the Mechanisms of Smoking Toxicity. Pereira-da-Silva T, Napoleão P, Costa MC, Gabriel AF, Selas M, Silva F, Enguita FJ, Ferreira RC, Carmo MM. J Clin Med. 2021 Feb 22;10(4):890.
MicroRNA Analysis from Acute to Convalescence in Crimean Congo Hemorrhagic Fever. Arslan S, Bayyurt B, Engin A, Bakir M. J Med Virol. 2021 Feb 28.
CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice. Vacante F, Rodor J, Lalwani MK, Mahmoud AD, Bennett M, De Pace A, Miller E, van Kuijk K, de Bruijn JB, Gijbels M, Williams TC, Clark MB, Scanlon JP, Doran AC, Montgomery R, Newby DE, Giacca M, O'Carroll D, Hadoke PW, Denby L, Sluimer JC, Baker AH. Circ Res. 2021 Feb 24.
MicroRNA-17-3p suppresses NF-κB-mediated endothelial inflammation by targeting NIK and IKKβ binding protein. Cai Y, Zhang Y, Chen H, Sun XH, Zhang P, Zhang L, Liao MY, Zhang F, Xia ZY, Man RY, Feinberg MW, Leung SW. Acta Pharmacol Sin. 2021 Feb 23.
Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer. Villa Del Campo C, Liaw NY, Gunadasa-Rohling M, Matthaei M, Braga L, Kennedy T, Salinas G, Voigt N, Giacca M, Zimmermann WH, Riley PR. Cardiovasc Res. 2021 Feb 18:cvab054.
TTN Circular RNAs Create A Backsplice Motif Essential for SRSF10 Splicing. Tijsen AJ, Cócera Ortega L, Reckman YJ, Zhang X, van der Made I, Aufiero S, Li J, Kamps SC, van den Bout A, Devalla HD, van Spaendonck-Zwarts K, Engelhardt S, Gepstein L, Ware JS, Pinto YM. Circulation. 2021 Feb 15.
Peripheral blood microRNAs and the COVID-19 patient: methodological considerations, technical challenges and practice points. Pinilla L, Benitez ID, González J, Torres G, Barbé F, de Gonzalo-Calvo D. RNA Biol. 2021 Feb 2.
miRNA-22 deletion limits white adipose expansion and activates brown fat to attenuate high-fat diet-induced fat mass accumulation. Lima VM, Liu J, Brandão BB, Lino CA, Balbino Silva CS, Ribeiro MAC, Oliveira TE, Real CC, de Paula Faria D, Cederquist C, Huang ZP, Hu X, Barreto-Chaves ML, Ferreira JCB, Festuccia WT, Mori MA, Kahn CR, Wang DZ, Diniz GP. Metabolism. 2021 Feb 4:154723.
Novel Transcript Discovery Expands the Repertoire of Pathologically-Associated, Long Non-Coding RNAs in Vascular Smooth Muscle Cells. Bennett M, Ulitsky I, Alloza I, Vandenbroeck K, Miscianinov V, Mahmoud AD, Ballantyne M, Rodor J, Baker AH. Int J Mol Sci. 2021 Feb 2;22(3):1484.
MiR-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload. Ramanujam D, Schön AP, Beck C, Vaccarello P, Felician G, Dueck A, Esfandyari D, Meister G, Meitinger T, Schulz C, Engelhardt S. Circulation. 2021 Feb 8.
JANUARY
Methotrexate attenuates vascular inflammation through an adenosine-microRNA dependent pathway. Yang D, Haemmig S, Zhou H, Pérez-Cremades D, Sun X, Chen L, Li J, Haneo-Mejia J, Yang T, Hollan I, Feinberg MW. Elife. 2021 Jan 8;10:e58064.
MicroRNAs to guide medical decision-making in obstructive sleep apnea: A review. Pinilla L, Barbé F, de Gonzalo-Calvo D. Sleep Med Rev. 2021 Jan 22;59:101458.
Diagnostic value of circulating microRNAs compared to high-sensitivity troponin T for the detection of non-ST-segment elevation myocardial infarction. Biener M, Giannitsis E, Thum T, Bär C, Costa A, Andrzejewski T, Stoyanov KM, Vafaie M, Meder B, Katus HA, de Gonzalo-Calvo D, Mueller-Hennessen M. Eur Heart J Acute Cardiovasc Care. 2021 Jan 4:zuaa034.
Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19. Jha PK, Vijay A, Halu A, Uchida S, Aikawa M. Front Cardiovasc Med. 2021 Jan 15;7:623012.
Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity. Cheng X, Shihabudeen Haider Ali MS, Moran M, Viana MP, Schlichte SL, Zimmerman MC, Khalimonchuk O, Feinberg MW, Sun X. Redox Biol. 2021 Jan 19;40:101863.
Long Non-coding RNA Aerrie Controls DNA Damage Repair via YBX1 to Maintain Endothelial Cell Function. Pham TP, Bink DI, Stanicek L, van Bergen A, van Leeuwen E, Tran Y, Matic L, Hedin U, Wittig I, Dimmeler S, Boon RA. Front Cell Dev Biol. 2021 Jan 11;8:619079.
Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p. Haddad G, Kölling M, Wegmann UA, Dettling A, Seeger H, Schmitt R, Soerensen-Zender I, Haller H, Kistler AD, Dueck A, Engelhardt S, Thum T, Mueller TF, Wüthrich RP, Lorenzen JM. J Am Soc Nephrol. 2021 Jan 21:ASN.2020060775.
Differential miRNA Expression in Human Macrophage-Like Cells Infected with Histoplasma capsulatum Yeasts Cultured in Planktonic and Biofilm Forms. Pitangui NS, de Lacorte Singulani J, Sardi JCO, de Souza PC, Rodríguez-Arellanes G, García-Pérez BE, Enguita FJ, Pavan FR, Taylor ML, Mendes-Giannini MJS, Fusco-Almeida AM. J Fungi (Basel). 2021 Jan 18;7(1):E60.
The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction. Spiroski AM, Sanders R, Meloni M, McCracken IR, Thomson A, Brittan M, Gray GA, Baker AH. Int J Mol Sci. 2021 Jan 19;22(2):E969.
Low miR-19b-1-5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio- Cerebrovascular Events in Patients With Acute Coronary Syndrome. Singh S, de Ronde MWJ, Creemers EE, Van der Made I, Meijering R, Chan MY, Hwee Tan S, Tang Chin C, Mark Richards A, Troughton RW, Yean Yip Fong A, Yan BP, Pinto-Sietsma SJ. J Am Heart Assoc. 2021 Jan 14:e017120.
Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila. Worpenberg L, Paolantoni C, Longhi S, Mulorz MM, Lence T, Wessels HH, Dassi E, Aiello G, Sutandy FXR, Scheibe M, Edupuganti RR, Busch A, Möckel MM, Vermeulen M, Butter F, König J, Notarangelo M, Ohler U, Dieterich C, Quattrone A, Soldano A, Roignant JY. EMBO J. 2021 Jan 11:e104975.