University Medical Center Göttingen
Heart Research Center Göttingen
Gerd Hasenfuß
Sara Khadjeh
We are interested to understand the mechanisms underlying the transition of cardiac remodeling from compensated hypertrophy with preserved heart function to heart failure. In order to develop new therapeutic strategies, we are particularly focusing on load-depended remodeling and the analysis of epigenetics and linc regulation of these processes.
Expertise
Subject areas
Cardiology, Heart failure, Transition to failure, Gene Expression, Epigenetics
Model systems
Human myocardium biopsies, hiPSC derived cardiomyocytes, TAC mouse model
Molecular biology techniques
DNA and RNA Ilumina sequencing (MiSeq and HiSeq) including library preparation and downstream data analysis such as Pathway and Cluster analyses, DNA extraction, total RNA extraction, mRNA extraction, PCR, quantitative PCR, Rapid Amplification of cDNA ends (RACE), Molecular cloning and in vitro site-directed mutagenesis, Whole mount in situ hybridization, Immunohistochemistry, RNA interference (RNAi), LNA GapmeR mediated inhibition of lncRNAs
Interested in collaborating on
Analysis of lncRNA function
