Maastricht University
Molecular Cardiology Maastricht
Leon de Windt
Our laboratory is interested in cardiac gene regulatory mechanisms by transcription factors and microRNAs that control pathological cardiac remodeling, an early step towards heart failure.
Selected publications on lncRNA
Long Non-Coding RNA Malat-1 is Dispensable During Pressure Overload-Induced Cardiac Remodeling and Failure in Mice
Peters T, Hermans-Beijnsberger S, Beqqali A, Bitsch N, Nakagawa S, Prasanth KV, de Windt LJ, van Oort RJ, Heymans S, Schroen B. PLoS One. 2016, 11(2):e015236.
Long noncoding RNA Chast promotes cardiac remodeling
Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T. Sci. Transl. Med. 2016, 8(326):326ra22.
Non-coding RNA in control of gene regulatory programs in cardiac development and disease
Philippen LE, Dirkx E, da Costa-Martins PA, De Windt LJ. J Mol Cell Cardiol. 2015, 89(Pt A):51-8.
Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases
Calore M, De Windt LJ, Rampazzo A. J Mol Cell Cardiol. 2015, 89(Pt A):27-34.
