Maastricht University

Cardiovascular Research Institute of Maastricht (CARIM)


Stephane Heymans
Blanche Schroen
Emma Robinson

The Center for Heart Failure Research is part of the Experimental Cardiology group based within the department of Cardiology and the Cardiovascular Research Institute Maastricht (CARIM). The expertise present in the laboratory accounts for a broad and in-depth knowledge on clinical, cellular and molecular processes in cardiovascular, immune and metabolic syndromes in a translational setting.


Molecular biology of non-coding RNAs, pathophysiological mechanisms in heart failure, genetics, cardiac histology and (inflammatory) cell biology.

Subject areas

  • molecular biology of non-coding RNAs

  • pathophysiological mechanisms in heart failure

  • genetics

  • cardiac histology and (inflammatory) cell biology

  • cellular and systemic metabolism


  • In situ hybridization

  • Non-radioactive northern blot

  • Bioinformatics

  • Deep phenotyping of heart failure models

  • Clinical and pre-clinical cardiac imaging

Interested in collaborating on

  • In vitro models of heart failure, preferrably human

  • RNA modifications analyses, RNA editing

  • ChIP and RNA IP

Selected publications on ncRNA and cardiovascular disease

Lnc'ing Ca2+, SERCA and cardiac disease
Vervliet T, Robinson EL, Roderick HLCell Calcium. 2018, 72:132-134.

Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity
Gast M, Schroen B, Voigt A, Haas J, Kuehl U, Lassner D, Skurk C, Escher F, Wang X, Kratzer A, Michalik K, Papageorgiou A, Peters T, Loebel M, Wilk S, Althof N, Prasanth KV, Katus H, Meder B, Nakagawa S, Scheibenbogen C, Schultheiss HP, Landmesser U, Dimmeler S, Heymans S, Poller W. J Mol Cell Biol. 2016, 8(2):178-81.

Long Non-Coding RNA Malat-1 is Dispensable During Pressure Overload-Induced Cardiac Remodeling and Failure in Mice
Peters T, Hermans-Beijnsberger S, Beqqali A, Bitsch N, Nakagawa S, Prasanth KV, de Windt LJ, van Oort RJ, Heymans SSchroen BPLoS One. 2016, 11(2):e015236.

CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis
Ounzain S, Micheletti R, Arnan C, Plaisance I, Cecchi D, Schroen B, Reverter F, Alexanian M, Gonzales C, Ng SY, Bussotti G, Pezzuto I, Notredame C, Heymans S, Guigó R, Johnson R, Pedrazzini TJ Mol Cell Cardiol. 2015, 89(Pt A):98-112.

Long noncoding RNAs in cardiac development and ageing
Devaux Y, Zangrando J, Schroen BCreemers EEPedrazzini TChang CPDorn II GWThum THeymans SNat Rev Cardiol. 2015, 12(7):415-25.

Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs
Ounzain S, Micheletti R, Beckmann T, Schroen B, Alexanian M, Pezzuto I, Crippa S, Nemir M, Sarre A, Johnson R, Dauvillier J, Burdet F, Ibberson M, Guigó R, Xenarios I, Heymans SPedrazzini TEur Heart J. 2014, 36(6):353-68a.


Universiteitssingel 50
6229 ER  Maastricht