Harvard Medical School

Department of Cardiology Boston Children's Hospital


Da-Zhi Wang

Our lab is mostly interested in the molecular mechanisms that control cellular differentiation and morphogenesis during animal development. We use muscle cells as our model system and we apply a variety of molecular, cellular, biochemistry and genetic approaches, including transgenic and knockout mouse models in our lab.

Selected publications on lncRNA

(MYO)SLIDing our way into the vascular pool of long noncoding RNAs
Naya FJ, Wang DZArterioscler Thromb Vasc Biol. 2016, 36(10).

LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity
Wu G, Cai J, Han Y, Chen J, Huang ZP, Chen C, Cai Y, Huang H, Yang Y, Liu Y, Xu Z, He D, Zhang X, Hu X, Pinello L, Zhong D, He F, Yuan GC, Wang DZ, Zeng C. Circulation. 2014, 130(17):1452-65.

Non-Coding RNAs Including miRNAs and lncRNAs in Cardiovascular Biology and Disease
Kataoka M, Wang DZCells. 2014, 3(3):883-98.

An epigenetic "LINK(RNA)" to pathological cardiac hypertrophy
Liu J, Wang DZCell Metab. 2014, 20(4):555-7.

Build a braveheart: the missing linc (RNA)
Kataoka M, Huang ZP, Wang DZCirc Res. 2013, 112(12):1532-4.


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