Academic Medical Center Amsterdam

Heart Failure Research Center, Department of Experimental Cardiology


Yigal Pinto
Esther Creemers

The HFRC is a research center within the Academic Medical Center (AMC) in Amsterdam, the Netherlands. The research groups bundled within the HFRC focus research primarily on the pre-clinical and clinical domains of congenital heart defects, cardiac arrhythmias and heart failure. Our research aims at understanding why an overloaded heart ultimately fails. Our leading thought is that the transition towards failure is governed by regulatory mechanisms that cause an accumulation of maladaptive changes. Our current focus is on genetic mechanisms and mechanisms involving RNA regulatory molecules like microRNAs, lncRNAs and RNA splicing as key regulators of maladaptive changes in the overloaded heart.


  • Cellular and mouse models of cardiac hypertrophy and heart failure (transcription factors, lncRNAs, circRNAs and microRNA mechanisms)

  • Genetics in heart failure and hypertrophy, particularly in relation to RNA binding proteins, transcription factors and non-coding RNAs

  • Translation towards clinical application by generating novel biomarkers of heart failure

Interested in collaborating on

  • RNA sequencing platforms

  • Novel mouse models

Selected publications on ncRNA and cardiovascular disease

RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling
van den Hoogenhof MM, Beqqali A, Amin AS, van der Made I, Aufiero S, Khan MA, Schumacher CA, Remme CA, Backs J, Verkerk AO, Baartscheer A, Pinto YMCreemers EECirculation. 2018.

RBM20 Regulates Circular RNA Production From the Titin Gene
Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EEPinto YMCirc Res. 2016, 119(9):996-1003.

RNA Splicing: Regulation and Disregulation in the Heart
van den Hoogenhof MM, Pinto YMCreemers EECirc Res. 2016, 118(3):454-68.

Function and Therapeutic Potential of Non-Coding RNAs in Cardiac Fibrosis
Creemers EE, Rooij Ev. Circ Res. 2016, 118(1):108-18.

Long noncoding RNAs in cardiac development and ageing
Devaux Y, Zangrando J, Schroen BCreemers EEPedrazzini TChang CPDorn II GW, Thum T, Heymans SNat Rev Cardiol. 2015, 12(7):415-25.


Meibergdreef 9
Amsterdam-Zuidoost, NH 1105