Shizuka Uchida, the guest editor for the upcoming Special Issue of High-Throughput: Microarrays in Non-Coding RNAs Profiling, calls for submission of papers that revisit the power of microarrays in profiling ncRNAs to facilitate functional studies.
The presence of non-coding RNAs (ncRNAs) is firmly fixed in various fields to overturn the previous concepts of junk DNA and transcriptional noise. Many ncRNAs have been shown to be functional as in the case of microRNAs (miRs) and more recent long non-coding RNAs (lncRNAs). It is predicted that the number of ncRNAs well surpasses that of protein-coding genes as organisms become more complex. Given such complexity, it is suggested that ncRNAs could be a key to decipher yet unknown mechanisms of physiological processes and disease status.
Although the emergence of next-generation sequencing (NGS) technology revolutionized the way genomics and transcriptomics studies are conducted, the past generation technology microarray still outperforms NGS for its specificity and ease of data analysis, which is increasingly noted by computational challenges due to the increased high-throughput of NGS resulting in an avalanche of data.
In this Special Issue, the guest editor would like to revisit the power of microarrays in profiling of ncRNAs to facilitate further functional studies of exciting molecules that hold more functions to be discovered.
Deadline for manuscript submissions: 31 December 2017.
Keywords
- algorithm
- bioinformatics
- circRNA
- detection method
- lncRNA
- microarray
- software