KU Leuven
Department of Cardiovascular Sciences, Laboratory of Experimental Cardiology
Llewelyn Roderick Maarten Vanhaverbeke, MD, PhD Researcher
We aim to understand how the epigenome, including long non-coding and microRNAs, contributes to determining and maintaining the phenotype of the adult cardiac myocyte and how degradation/remodelling of the adult cardiac myocyte epigenome underlies phenotypic changes associated with disease and ageing. Access to human data and animal facilities. PhD Researcher in the field of biomarkers and transcriptomics in ischemic heart disease and cardiac arrest.
Expertise
Gene expression analysis
Cardiac myocyte nuclei isolation
Epigenomics
Small rodent modeling of cardiovascular disease and cardiac imaging
Cardiac myocyte electrophysiology and calcium signalling
RNA profiling in ischemic heart disease
Ischemia-reperfusion injury in human, cardiac MRI
Ischemia-reperfusion in animal models (porcine, canine)
Inflammatory response in myocardial infarction
Interested in collaborating on
We are open to collaboration in all aspects of our work – most notably to gain greater expertise in analysis of deep RNA sequencing data to identify novel transcripts relevant to cardiac biology and disease.
Also structural (RNA) biology expertise – understanding/modelling secondary structures and interactomes.
Selected publications on lncRNA
Lnc'ing Ca2+, SERCA and cardiac disease
Vervliet T, Robinson EL, Roderick HL. Cell Calcium. 2018, 72:132-134.
