Institute of Cardiology
Department of Heart Failure and Transplantology
Przemyslaw Leszek
We work as a clinical center of cardiology and cardiosurgery with the highest reference score. The clinical activity in the Institute focuses on interventional treatment of acute coronary syndromes, diagnosis and treatment of coronary artery disease and cardiac insufficiency as well as acquired and congenital heart defects. The clinical activity also includes diagnosing and treating arterial hypertension, arrhythmia and comprehensive cardiac care of patients with oncological disease. The procedures performed at the Institute include cardiosurgery and heart transplantation as well as all kind of imaging diagnostics.
Expertise
Pathophysiology and remodeling of failing myocardium taking into account many clinical aspects:
The expression of proteins influencing the circulation of calcium ion in failing heart muscle with various etiology of heart failure (overload/unload left ventricle) (human model)
The iron metabolism, erythropoietin system in failing heart muscle in advanced heart failure (human and animal model)
The expression of natriuretic hormones, receptors for natriuretic hormones (with functional evaluation) in advanced heart failure (human model)
The optimization of heart rate in various phases of severe heart failure (human and animal model)
Interested in collaborating on
As a clinical center of cardiology and cardiosurgery, we are involved in several international collaborations with regard to heart failure and other cardiology diseases. We are open to any research proposal, which is based on human subjects. We treat the full profile of cardiac diseases while also having experience in running projects involving basic science.
Selected publications on lncRNA
Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction
Vausort M, Salgado-Somoza A, Zhang L, Leszek P, Scholz M, Teren A, Burkhardt R, Thiery J, Wagner DR, Devaux Y. J Am Coll Cardiol. 2016, 68(11):1247-8.
