School of Medicine
Understanding the epigenetic mechanisms that underlie heart failure will facilitate drug discovery process and the development of epigenetic therapy for heart failure. Ching-Pin Chang, M.D., Ph.D, is applying his research discoveries in fetal heart development to adult heart disease and planning to take his basic science discoveries into clinical trials.
Heart failure, Heart development, Genetics, Epigenetics.
The Chang Lab focuses on the mechanisms of cardiovascular development, particularly how the three major types of cardiac cells (endocardial, myocardial and epicardial cells) and neural crest cells interact with each other to generate heart tissues. We are interested in the transcriptional and signaling events that coordinate their interactions and assembly into heart tissues. The long-term goal is to understand the developmental mechanisms that control tissue formation and recapitulate the developmental processes for therapeutic or regenerative purposes. Furthermore, we have generated mouse models of cardiomyopathy and models that allow us to study the repair mechanisms of vascular injury in adult. We aim to applying lessons learned from our developmental studies to investigating the mechanisms of adult diseases.
Selected publications on lncRNA
Epigenetic and lncRNA regulation of cardiac pathophysiology
Chang CP, Han P. Biochim Biophys Acta. 2016, 1863(7 Pt B):1767-71.
A long noncoding RNA protects the heart from pathological hypertrophy
Han P, Li W, Lin CH, Yang J, Shang C, Nurnberg ST, Jin KK, Xu W, Lin CY, Lin CJ, Xiong Y, Chien HC, Zhou B, Ashley E, Bernstein D, Chen PS, Chen HS, Quertermous T, Chang CP. Nature. 2014, 514(7520):102-6.